All lanes of Augusta Road/US-1 at Tarrar Springs Road in Lexington have reopened.
The road was closed because of a crash, according to the Lexington Police Department.
Lexington County Fire Service and EMS responded quickly to the incident.
Several people were transported to the hospital from the scene, according to the LPD.
The collision was caused by a distracted driver who was driving too fast for conditions, said police.